In particular, the Asn118Asn (rs11615; c.354G>A) variant in ERCC1 (13), and the Lys751Gln (rs13181; c.2251A>C) and Asp312Asn (rs1799793; c.934C>T) variants in ERCC2 (11,12,14) have been associated with the risk of cancer in a variety of populations. The gene discussed is ERCC2; the disease is cancer.