Fig. 1A–D shows representative examples of hTERT expression in esophageal cancer samples and Fig. 1E–H shows representative examples of UBE2D3 expression. According to the aforementioned staining intensity and extent scores, Fig. 1A, B, E and F demonstrated high expression levels, however, Fig. 1C, D, G and H demonstrated low UBE2D3 expression levels. The gene discussed is UBE2D3; the disease is esophageal cancer.