IL-6 induces AGS gastric cancer cell invasion via activation of the cellular-Rous sarcoma/ras homolog family member A (RhoA)/Rho-associated, coiled-coil-containing protein kinase signaling pathway, and RhoA expression may be a potential prognostic factor in gastric adenocarcinoma patients (55). Here, RHOA is linked to gastric adenocarcinoma.