Various studies have demonstrated that the presence of numerous single nucleotide polymorphisms (SNPs) is associated with increased gastric cancer susceptibility; for example, excision repair cross-complementation group 1, CDH1, IL-10, IL-1, IL-6, VEGF and FAS gene SNPs have been found to be associated with the risk of gastric cancer (Table II) (93–101). The gene discussed is CDH1; the disease is gastric cancer.