The hypermethylation of various genes, such as cadherin 1 (CDH1) (82), coiled-coil domain containing protein 67 (83), methylated in tumors 31 (84), p16 (85), runt-related transcription factor 3 (85), E-cadherin (86), hMHL1 (87) and wingless-type MMTV integration site family, member 5A (88), has been identified to be associated with the prognosis of gastric cancer. This evidence concerns the gene CDH1 and gastric cancer.