For example, Kim et al (42) evaluated the expression of various growth factors/receptors in gastric adenocarcinoma, including EGFR, VEGF, VEGF-D, VEGFR-2, VEGFR-3, TGF-α, TGF-β1 and TGF-β RII, using a log rank test to identify that VEGF-D and VEGFR-2 expression was associated with patient survival, and Cox regression analysis to determine that advanced stage gastric cancer and positive expression of VEGF-D were poor prognostic factors. This evidence concerns the gene TGFB1 and gastric adenocarcinoma.