CASP3 and neoplasm: In the present study, the IHC and Western Blot results both showed that the active proteins cleaved Caspase-3 and cleaved Caspase-9 were markedly upregulated in the transplanted tumor of the TNSE treated groups compared with the control group (P < 0.01, P < 0.05, Figures 9(b)–9(d), 10(b)–10(d), 11, and 12), which suggests that TNSE could induce tumor apoptosis and might contribute to the decrease of the tumor size.