When assessing the independent effect of the potential risk factors on ORPF occurrence in multivariate analysis, cholangitis, preoperative albumin, intraoperative blood transfusion, texture of the remnant pancreas, and professional group or not were the significant associated factors (all P < 0.05), whereas the effect of pancreatic duct stent drainage methods had no independent effect on ORPF. This evidence concerns the gene ALB and cholangitis.