Interestingly, the two dominating interactions in the subpopulations (the SPHK1 and ASAH1 interactions, Tables 1, 2, and see below) were not detected, suggesting that, accepting the assumption that blood pressure states and hypertension are heterogeneous physiological conditions, simply partition of the population by gender was not sufficiently discriminatory. Here, SPHK1 is linked to hypertensive disorder.