Hanaoka et al. described that sMIC can also induce loss of the CD3ζ signaling adaptor, which occurs in T cells and NK cells in cancer patients, after NKG2D signaling leads to Fas-mediated caspases 3/7 activation and cleavage of CD3ζ (72), leading to T cell and NK cell dysfunction. Here, KLRK1 is linked to cancer.