Additionally, the most frequent molecular abnormalities presented in astrocytomas (LOH 10p and LOH 10q; TP 53 mutations; EGFR amplification/chromosome 7 polysomy; EGFRvIII variant; CDKN2A deletions; IDH1 mutations) were used as markers of neoplastic cells at the DNA level [15]-[18]. Here, IDH1 is linked to astrocytoma (excluding glioblastoma).