Further, pretreatment of plasma with immobilized papain could also inhibit the induction of IL-8, IFN-α and TNF-α in a dose dependent manner (Figure 2C, P < 0.05), suggesting that the immunoglobulin (Ig) component was also important for the stimulatory activity of NSCLC plasma. Here, TNF is linked to non-small cell lung carcinoma.