And the calcium depositions in MM osteoblasts with bortezomib (8.83 ± 1.94) was more than those without bortezomib (P < 0.01), but less than those of normal controls (P < 0.01) (Figure 2c).The expressions of BMP-2 mRNA (308 bp) were positive in normal osteoblasts and MM patients’ osteoblasts co-cultured with bortezomib, but were negative in those of MM patients’ osteoblasts without bortezomib (Figure 4b). Here, BMP2 is linked to Miyoshi myopathy.