Though the epistatic effect of combined SNP in NLRP3 and CARD8 (Q705K, rs35829419 and C10X, rs2043211) was found to be associated with the RA susceptibility and severity, the replication of the results was not observed in the prospective study from the same research group [6, 56]. The gene discussed is NLRP3; the disease is rheumatoid arthritis.