Since its discovery, the genetic alterations in the genes encoding the NLRP3 inflammasome have increasingly attracted the research interest, with respect to several diseases with an inflammatory background as a possible predisposing factor in diseases like inflammatory bowel disease (IBD) [3, 4], rheumatoid arthritis (RA) [5, 6], Alzheimer's disease (AD) [7], type 1 diabetes (T1D) [8], and atherosclerosis [9, 10]. This evidence concerns the gene NLRP3 and rheumatoid arthritis.