Regarding the variants of the CARD8 gene, the C10X variant (rs2043211; Figure 2) was found to be associated with lower expression of CARD8 in plaque as well as with the lower levels of CRP and MCP-1 in plasma, but the SNP showed no association with the risk of myocardial infarction in Swedish cohorts [78]. Here, CRP is linked to myocardial infarction.