EPHA2 and ovarian neoplasm: To explore whether MSV-EphA2 siRNA treatment can likewise decrease the expression of MMP-9 in HeyA8-MDR-induced ovarian tumors, and whether the reduction is also correlated with decreased tumor burden, we performed IHC using a specific anti-human MMP-9 antibody on sections of tumor tissues collected from mice treated with either MSV-EphA2 or MSV-control siRNA.