TPK1 knockdown also caused significant radiosensitization in the highly radioresistant SQ20B head and neck tumor line (SER10 of 1.14; p <0.001) and the breast ductal carcinoma cell line BT-549 (SER10 of 1.19; p<0.001; Fig. 2A). Here, TPK1 is linked to breast ductal adenocarcinoma.