In this study, we aimed to decipher the role of DKK-1 in CRC by investigating its expression in cultured human colon carcinoma cells and in normal small intestine and colon mucosa and colorectal cancer, and by assessing the relation of DKK-1 expression with the clinical outcome and the benefit to systemic therapy in CRC patients. The gene discussed is DKK1; the disease is colorectal carcinoma.