MAPK8 and cancer: Previous studies mainly focus on the cytotoxic effects of PL in cancer cells and various ROS-dependent cell death mechanisms, e.g., apoptosis [36-38], autophagic cell death [16, 39], cell cycle arrest [17, 38], GSTP1 [13], p38 [9, 39], JNK [9, 38], Erk [15], which have been proposed in different cancer cell lines.