Overall, our results indicate for the first time that BSN can inhibit constitutive and inducible STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 proteins, as well as can enhance the effects of paclitaxel through the downregulation of gene products that mediate tumor cell survival, proliferation, invasion, and metastasis in human lung cancer. This evidence concerns the gene PIAS3 and lung cancer.