STAT3 and non-small cell lung carcinoma: We evaluated the effect of BSN and paclitaxel on constitutive phospho-STAT3 level in NSCLC tumor tissues by immunohistochemical analysis and found that BSN and paclitaxel alone significantly downregulated the expression of phospho-STAT3 in tumor tissues compared with the control group, and the combination of these two was significantly more effective (Fig. 7A, upper panels).