STAT3 and neoplasm: Overall, our results indicate for the first time that BSN can inhibit constitutive and inducible STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 proteins, as well as can enhance the effects of paclitaxel through the downregulation of gene products that mediate tumor cell survival, proliferation, invasion, and metastasis in human lung cancer.