Genomic Regions Enrichment of Annotations Tool (GREAT) analyses [43] on distal intergenic regions which exhibited overlapping peaks of H3K27ac, H4K12ac and BRD4 demonstrated an enrichment of estrogen and breast cancer luminal upregulated and basal downregulated-related pathways (Fig. S2B-C). This evidence concerns the gene BRD4 and breast carcinoma.