PKM and neoplasm: High PKM2 expression was also closely associated with higher serum α-Fetoprotein level (P < 0.001), advanced clinical stage (P < 0.0001), larger tumor (P = 0.005), vascular invasion (P < 0.0001) and more multiple nodular tumor (P = 0.027) in all cases enrolled into this study (Supplementary Table 5).