AKT1 and acute lymphoblastic leukemia: GSK690693 is a small molecule ATP-competitive inhibitor of the pro-survival kinase Akt, is a pan-Akt kinase inhibitor, has been preclinically tested in osteosarcoma and ALL xenografts and is now in phase I of clinical trials in sarcomas, neuroblastoma, non-glioblastoma brain tumors and lymphoma [13, 14].