LARGE1 and neoplasm: Due to the ability of MP-A08 to induce apoptosis in Jurkat cells we then tested its affects on the growth of a range of solid cancer cell lines, including three from the NCI60 human tumor cell line panel (A549 lung adenocarcinoma cells, and MCF-7 and MDA-MB-231 breast adenocarcinoma cells) (Figure 6A), as well as BJ7 human foreskin fibroblasts transformed via the expression of V12-Ras, the telomerase catalytic subunit and the SV40 large and small T antigens [40] and the parental untransformed foreskin fibroblast line, BJ1 (Figure 6B).