There were no significant differences in the incidence of HCC in relation to the presence of CP only, PC only, or both PC and CP mutations when looking at the entire study population, treatment-experienced patients, treatment-naïve patients, or monoinfected patients (excluding coinfected patients), nor was there a significant difference in the distribution of HBV genotype in patients with and without HCC in any of these subgroups. Here, CP is linked to hepatocellular carcinoma.