CP and pachyonychia congenita: Furthermore, various studies have reported (1) no correlation between PC/CP mutations and HBV DNA levels [17], (2) an association between most CP and PC mutations with significantly reduced viral replication [18], (3) an association between up-regulation of viral replication with CP mutations other than those at 1762/1764 [19], and (4) an association between increased viral replication and the PC mutation [20].