Recent evidence has demonstrated that PARP-1 activity is enhanced in selected tumors and likely contributes to tumor progression (Brenner et al, 2011; Do & Chen, 2013; Luo & Kraus, 2012; Schiewer et al, 2012a,b; Kedar et al, 2012; Horton & Wilson, 2013; Horton et al, 2014; Schiewer & Knudsen, 2014). Here, PARP1 is linked to neoplasm.