These include the following: (1) amplification of the CCND1 gene (observed frequently in breast, pancreatic, skin, lung, and head and neck cancers) (Arnold & Papanikolaou, 2005; Garcea et al, 2005; Thomas et al, 2005; Li et al, 2006; Gautschi et al, 2007), (2) translocation of the CCND1 locus to IGH enhancer elements (seen in nearly all cases of mantle cell lymphoma) (Bosch et al, 1994; Bigoni et al, 1996), and (3) mutations in the sequences encoding the cyclin D1 PEST domain (which occur in esophageal cancers) (Benzeno et al, 2006). Here, CCND1 is linked to head and neck cancer.