ALK and neoplasm: Indeed, more recent large-scale sequencing studies have revealed that NB tumours have an average of only 12 amino-acid-changing mutations per tumour, with the highest recurring mutated gene, ALK, being mutated in only 6-10% of tumours, suggesting that the genome of NB is largely intact (Molenaar et al., 2012; Pugh et al., 2013).