AKT1 and B-cell chronic lymphocytic leukemia: In CLL, it was recently reported that IGF1R is involved in the activation of phosphorylation cascades such as Ras/Raf/MAPK and PI3K-Akt [28].These pathways are emerging as important survival and proliferation signals in CLL and represent an attractive target of novel drugs (i.e ibrutinib and idelasilib) [29–31].