IGF1R and B-cell chronic lymphocytic leukemia: Recently it was shown that IGF1R was generally over-expressed in CLL compared to healthy B-cells, and was implicated in the activation of the PI3K/Akt and MAPK pathways; notably, distinct CLL groups [i.e del(11)(q13), del(17)(p13) and trisomy 12 patients] were found to be associated with a significant higher IGF1R expression compared to other patients [11].