CFH and age-related macular degeneration: The Rotterdam Eye Study previously examined the incidence of AMD in patients with prior cataract who were CFH Y402H carriers, and found that the OR for dry AMD in CFH carriers after cataract surgery increased in an allele-dose manner with an OR of 2.30 (95% CI: 0.28–18.83) for non-carriers, 3.31 (95% CI: 1.23–8.91) for heterozygotes, and 4.02 (95% CI: 1.37–11.79) for homozygous CFH Y402H carriers [36].