VEGFA and neoplasm: PTE on the MRI, however, has been attributed to several other factors including tumor size [40,41], location [17,42,43], histological grading [17,19,44], tumor vascularity [19,29,40,45], tumor-related venous obstruction [29,46],impairment of blood-brain barrier [2,20,23,29,46],presence of pial-cortical blood supply [29,47],vascular endothelial growth factor [45] and irregular tumor margin [29,41].Thus the presence of PTE alone might not accurately predict the aggressiveness of meningioma.