LEDGF/p75 is a key co-factor tethering HIV DNA to host DNA and directing viral DNA integration.[46] Depletion or knockdown of LEDGF/p75 substantially reduces infectivity of the virus.[47] If lower FBXO10 expression reduces available LEDGF/p75, then it may contribute to protection from HIV infection. Here, FBXO10 is linked to HIV infectious disease.