TIAM1 and neoplasm: Furthermore, the decrease in endogenous miR-29c levels using a miR-29c inhibitor resulted in metastatic tumor invasion by up-regulating the extracellular matrix targets or related proteins [10], which was consistent with the data suggesting that increased expression of miR-29c impedes cell migration and invasion by targeting TIAM1 in both SUNE-1 and CNE-2 cells [57].