For instance, heparanase expression was shown to be upregulated in a number of animal models of renal disease: passive Heymann nephritis [12], puromycin aminonucleoside nephrosis (PAN) [13], Adriamycin nephropathy (ADR-N) [14,15], anti-glomerular basement membrane (GBM) nephritis [16], and diabetic nephropathy [17,18]; and in renal epithelial and endothelial cells cultured in ambient high glucose concentration [18]. This evidence concerns the gene HPSE and kidney disorder.