Given that the expression of p15 and p16 (tumor suppressors) was down-regulated upon curcumin and emodin treatment in cervical cancer cells, their growth inhibitory effects may have taken an alternate route through Bax induction together with the down regulation of Bcl-2, but whether curcumin and emodin influence other proteins involved in the tumor suppressive role of TGF-β needs to be deciphered. This evidence concerns the gene CDKN2B and neoplasm.