This is the first report showing down regulation of TGF-β signaling pathway by curcumin and emodin in cervical cancer cells and their effect was independent of the presence of TGF-β suggesting their suitability to combat carcinogenesis during early as well as advanced stages of cancer wherein expression and secretion of TGF-β are differentially regulated [53]. The gene discussed is TGFB1; the disease is cancer.