Inhibition of TGF-β signaling by down-regulation of TGF-β ReceptorII and alterations in the expression of Snail, Twist, Vimentin, E-cadherin, P-Smad2, β-catenin and GSK3-β by curcumin in triple negative breast cancer cells suppressed EMT [54]. Here, SMAD2 is linked to triple-negative breast carcinoma.