SMAD3 and inflammatory bowel disease: However, there are evidences for other prioritized SNPs as well, such as, rs6859219 (ANKRD55) is found to be associated with MS risk [62]; rs6927172 (TNFAIP3) is found to be associated with anti-TNF therapy response among IBD patients [63]; rs4246215 (FEN1) is associated with DNA damage [64] and increased risk of colorectal cancer [65]; and rs17293632 (SMAD3) is found to be associated with the recurrence of surgery in CD patients [66].