Using an additive model, we estimated the FOXC1 transactivation ability associated with each glaucoma genotype as the mean activity of the two alleles and inferred two glaucoma associated activity intervals, which ranged from approximately 50% to 60% and from 130% to 150% compared to the wild-type FOXC1 genotype (Fig. 9). This evidence concerns the gene FOXC1 and glaucoma.