Melanoma-derived PAEP significantly inhibited the PHA-stimulated secretion of both IL-2 (decreased by 17.1%, p<0.05) and IFN-γ (decreased by 61.7%, p<0.05) from Th1 cells (Fig. 2F), but did not affect those secretions of Th1-free T helper cells. The gene discussed is IFNG; the disease is melanoma.