TNF and infection: The most discriminative signature (AUC of 0.95±0.03 attained on the training-set) used logistic regression to integrate the levels of the following viral- and bacterial-induced proteins (Fig. 2): TRAIL (member of the tumor necrosis factor family implicated in programmed cell death) [47], IP-10 (small cytokine implicated in multiple cellular processes including chemotaxis and cell growth inhibition) [48], and CRP (acute phase protein with diverse roles in tissue injury, infection and other inflammation processes) [49].