At a replication p<0.05 (Bonferroni corrected), 13 unique genes that were identified in the FHS were replicated in the Illumina cohorts, including 10 for SBP (CD97, TAGAP, DUSP1, FOS, MCL1, MYADM, PPP1R15A, SLC31A2, TAGLN2, and TIPARP), 5 for DBP (CD97, BHLHE40, PRF1, CLC, and MYADM), and 2 for HTN (GZMB and MYADM) (Table 2). The gene discussed is PPP1R15A; the disease is hypertensive disorder.