In renal cell carcinoma (RCC), but not in normal tissues, the LTR2C full length CT-RCC HERV-E element located on chromosome 6 at position 6q15 has been shown to encode a highly immunogenic 10 amino acid env peptide (CT-RCC-1) that can be considered to be a tumour-specific antigen [49]. The gene discussed is RCC1; the disease is renal cell carcinoma.