SLC5A2 and chronic kidney disease: In addition, in 5/6 nephrectomized rats it has been reported that SGLT2 in the isolated renal apical (brush-border) membrane vesicles was markedly decreased in nephrectomized rats compared with controls [26] and that the mRNA expression levels of SGLT2, but not SGLT1, were markedly depressed, suggesting that loss of SGLT2 during CKD could reduce the single nephron maximal glucose reuptake and increase the risk of renal glycosuria.