In APS monocytes, double stimulation decreased mRNAs of CCL2 (0.058 ± 0.012 versus 0.023 ± 0.008, P = 0.03) and IL-1β (0.702 ± 0.150 versus 0.224 ± 0.066, P = 0.006) compared to those in control culture with media. This evidence concerns the gene IL1B and autoimmune polyendocrinopathy.