Upon 4-hour treatment of APS monocytes with LPS, the transcriptional levels of TLR2 (untreated versus LPS-treated; 0.017 ± 0.008 versus 0.113 ± 0.017, P = 0.0007), IL-23 (0.016 ± 0.006 versus 0.374 ± 0.138, P = 0.02), CCL2 (0.058 ± 0.012 versus 0.183 ± 0.048, P = 0.02), CXCL10 (0.009 ± 0.003 versus 1.645 ± 0.409, P = 0.0009), IL-1β (0.702 ± 0.15 versus 1.543 ± 0.271, P = 0.015), and IL-6 (0.028 ± 0.009 versus 0.098 ± 0.021, P = 0.03) were elevated as compared with untreated cells. The gene discussed is IL6; the disease is autoimmune polyendocrinopathy.