The addition of low concentrations of ATP markedly reduced the mRNA levels of a number of genes in APS patients in comparison to those cells cultured only with LPS: IL-1β (1.543 ± 0.271 versus 0.224 ± 0.066, P = 0.0001), IL-6 (0.098 ± 0.02 versus 0.033 ± 0.008, P = 0.017), NLRP3 (0.207 ± 0.073 versus 0.064 ± 0.035, P = 0.014), IL-23 (LPS versus LPS + ATP; 0.374 ± 0.138 versus 0.030 ± 0.015, P = 0.04), and CCL2 (0.183 ± 0.048 versus 0.023 ± 0.008, P = 0.002). Here, NLRP3 is linked to autoimmune polyendocrinopathy.