Expression of TLR2 (controls versus APS (mean ± SD); 0.107 ± 0.033 versus 0.026 ± 0.014, P = 0.03), IL-1β (1.690 ± 0.467 versus 0.394 ± 0.09, P = 0.002), IL-6 (0.107 ± 0.046 versus 0.004 ± 0.001, P = 0.020), IL-23 (0.125 ± 0.068 versus 0.017 ± 0.005, P = 0.030), CCL2 (0.076 ± 0.027 versus 0.008 ± 0.002, P = 0.018), and STAT3 (0.164 ± 0.072 versus 0.029 ± 0.018, P = 0.028) was significantly higher in monocytes from healthy subjects compared with APS patients. This evidence concerns the gene STAT3 and autoimmune polyendocrinopathy.