IL10 and autoimmune polyendocrinopathy: In APS monocytes double stimulation increased production of IL-10 (143.7 ± 38.76 pg/mL versus 111.2 ± 39.62, P = 0.008) compared with LPS cultivation; in monocytes from healthy donors double stimulation resulted in increased production of IL-10 (114.4 ± 27.31 versus 2.988 ± 2.988, P = 0.008) compared with control cultivation (Figure 2).