Nerve density is higher in tumor foci as compared to non-tumoral regions and healthy prostates, respectively (131), and correlates with increased proliferation of PCa cells and activation of cell survival pathways (including PTEN/Akt-1 and downstream effectors FKHR and GSK, as well as NF-κB and downstream effectors PIM-2 and c-Myc) (132). The gene discussed is AKT1; the disease is neoplasm.