Additionally, in core needle biopsies from PCa patients with Gleason score 8–10 who received primary radiotherapy, CgA immunostaining >1% correlated with less favorable biochemical control, clinical failure, distant metastases (sixfold), and cancer-specific survival (almost fivefold) rates as compared to CgA immunostaining <1% or negative CgA immunostaining, respectively (92). Here, CGA is linked to cancer.