CGA and neoplasm: An in-depth, all-organ-site histological, genetic, phenotypical, and clinical comparative analysis of focal NED is warranted; (ii) focal NED correlates with tumor aggressiveness and poor prognosis, particularly in patients receiving ADT; (iii) CgA is the most reliable immunohistochemical NED marker; (iv) core-needle biopsies provide an accurate snapshot of NED.