Many type 1 diabetic patients through achieving ideal HbA1c goals avoid the microvascular complications of diabetes (retinopathy, nephropathy, and neuropathy) while at the same time increasing body weight which results not only in resistance to the action of insulin but also in an increased risk of macrovascular complications (coronary artery, cerebrovascular, and peripheral vascular diseases). The gene discussed is INS; the disease is kidney disorder.