CRS increased the expression of aromatase (Cyp19a1), which catalyzes the conversion of androgens to estrogens, and the estrogen receptor Esr1 (H = 5.37, p = 0.021 and H = 5.97, p = 0.015, respectively, Figures 4C,D). Here, CYP19A1 is linked to congenital rubella syndrome.