Also addressed in this Research Topic is the role of TWEAK/Fn14 in the pathological remodeling underlying other inflammatory diseases, namely cardiovascular diseases and obesity-associated Type-2 diabetes (6, 7), as well as in myocardial remodeling leading to heart failure (8), and a common theme also addressed in these articles is the potential use of soluble TWEAK as a biomarker for cardiovascular diseases. The gene discussed is TNFSF12; the disease is obesity due to melanocortin 4 receptor deficiency.