Consistent with the protective effects seen in experimental studies interfering with C5 function (Manthey et al., 2011; Shagdarsuren et al., 2010), treatment with anti-C5 antibody (Pexelizumab) resulted in significantly reduced mortality in ST-elevated myocardial infarction (STEMI) patients (Granger et al., 2003). The gene discussed is C5; the disease is ST Elevation Myocardial Infarction.