They commonly include RNA-binding proteins related to the pathogenesis of various neurodegenerative diseases, such as TDP-43 and FUS (related to the pathology of ALS and FTD), SMN (related to SMA pathology), ataxin-2 (related to SCA2), optineurin (related to primary open angle glaucoma and ALS12), and angiogenin (involved in ALS9 pathology). The gene discussed is ATXN2; the disease is frontotemporal dementia.