High levels of pro-angiogenic gene expression have also been documented in AD brains using genome-wide expression profiling and includes the expression of vascular endothelial growth factor (VEGF), HIF-1α, angiopoietin-2 and thrombin (Pogue and Lukiw, 2004; Thirumangalakudi et al., 2006). This evidence concerns the gene VEGFA and Alzheimer disease.