MAPT and Alzheimer disease: The histological hallmarks of AD throughout the brain (mainly in the region of hippocampus and neocortex) are intracellular deposition of hyperphosphorylated form of the microtubule associated protein tau called neurofibrillary tangles (NTF) and extracellular accumulation of amyloid β peptides (Aβ peptides) in senile plaques (Bloom, 2014).