IL6 and Alzheimer disease: Several studies indicated elevated levels of other inflammatory mediators in AD cerebral microcirculation, where endothelial cells overexpress adhesion molecules (MCP-1, ICAM-1, CAP37), and inflammatory and stress markers such as TNFα, TGF-β, interleukins (IL-1β, IL-6, IL-8) and matrix metalloproteases (MMPs; Grammas and Ovase, 2001; Grammas et al., 2002; Thirumangalakudi et al., 2006; Yin et al., 2010; Grammas, 2011).