KCND2 and autism: Moreover, rare variants in KCND2 have been identified in individuals with autism, namely: a submicroscopic de novo deletion (Okamoto et al., 2011), three translocation breakpoints (at 7q22.1, 7q31.2 and 7q31.3) potentially deleterious (Scherer et al., 2003), and three substitution variants, (N544S; F538S; R539L) reported in three independent cases of autism (Mikhailov et al., 2008).