FMR1 and fragile X syndrome: Kv4.2 channel expression may also participate in establishing the conditions for the development of ASDs, given that Kv4.2 mRNA can bind to the fragile X mental retardation protein (FMRP), which is associated to fragile X syndrome (FXS), the most common monogenic cause of autism and inherited intellectual retardation (Garber et al., 2008) often accompanied by seizures and poor motor coordination (Garber et al., 2008).