CHRNA4 and autosomal dominant nocturnal frontal lobe epilepsy: Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is caused by mutations in the CHRNA4, CHRNA2, CHRNB2, or KCNT1(Slack) genes (Steinlein et al., 1995; De Fusco et al., 2000; Aridon et al., 2006; Heron et al., 2012).