In humans, the KCNMA1 gain-of-function mutation D434G has been found in patients suffering from KCa1.1-channelepsy that is characterized by generalized epilepsy and paroxysmal dyskinesia (Du et al., 2005; D’Adamo et al., 2013). This evidence concerns the gene KCNMA1 and idiopathic generalized epilepsy.