Further, miRNA-146a targets the 3′-UTR of mRNAs encoding signaling proteins involved in the innate immune and inflammatory response, including complement factor H (CFH) and IRAK-1, and both compartmentalized CFH and IRAK-1 deficiencies are observed in MS (Taganov et al., 2006; Cui et al., 2010; Ingram et al., 2014; Stürner et al., 2014). Here, IRAK1 is linked to myeloid sarcoma.