Our data indicate that there are significant differences in the distribution of allelic and genotypic among primary postmenopausal osteoporosis patients and healthy controls for the p.Gly14Ala and p.His305Gln genetic variants of VDR gene (P values < 0.05, Table 2), and these two genetic variants were statistically associated with the decreased susceptibility to BMD and osteoporosis (P values < 0.05, Table 2). The gene discussed is VDR; the disease is osteoporosis.