Indeed, 2-DG treatment significantly heightened the sensitivity of cancer cells to bleomycin-induced killing and importantly, restoration of histone acetylation by inhibition of HDAC abolished the effect of 2-DG (Figure 6B), implicating that 2-DG sensitized cancer cells to the DNA damage agent via inducing decreased histone acetylation and subsequent condensed chromatin structure. Here, HDAC9 is linked to cancer.