However, for 95 patients with Stage III melanoma, cytoplasm p27 showed a hazard ratio of 1.78 (P = 0.032, 95% CI: 1.05–3.02, Table 5), and p27 expression dramatically affected patient survival (P = 0.018, Log-rank test) (Figure 2c). This evidence concerns the gene CDKN1B and melanoma.