MMP2 and melanoma: For Stage II melanomas, both MMP2 and p27 showed significant prognostic values based on survival and Cox-regression analyses (Table 3, Supplementary Figure S3c and S3d), MMP2, however, appeared to have stronger P values in both analyses (P = 0.004 vs 0.028, survival analysis, Log-rank test; P = 0.001 vs 0.004, Cox regression analysis), as compared to p27.